314 Area Code: St. Louis's Number by the Arch

314 has served St. Louis since 1947, tying the city's beer-brewing heritage, biotech growth, and role as the historic "Gateway to the West" under one of the Midwest's most recognizable prefixes.

History & Coverage

314 originally covered eastern Missouri. As the metro grew, 636 and 573 split off to serve surrounding counties, leaving 314 concentrated on the city of St. Louis and inner suburbs.

Why Businesses Choose 314

• Brewing industry legacy: as the historic home of Anheuser-Busch, 314 carries deep beverage-industry credibility
• Biotech and plant science hubith Bayer Crop Science and the Danforth Plant Science Center based locally, 314 is tied to a growing agtech and biotech cluster
• Gateway city symbolism: the Gateway Arch gives St. Louis strong tourism and civic branding tied to its area code

Key Industries & Neighborhoods

Downtown St. Louis and the Central West End anchor healthcare, biotech, and corporate headquarters, while the historic Soulard district adds brewing heritage and hospitality business.

Fun Facts

• St. Louis is one of the largest agricultural biotech research hubs in the country, often called the "Ag Innovation Corridor"
• The Gateway Arch, the tallest man-made monument in the US, sits within the 314 footprint

Conclusion

For brewing, biotech, and logistics companies along the Mississippi River corridor, 314 remains a deeply established number tied to St. Louis's historic and economic identity.